Microwave assisted synthesis of quinoxaline derivatives

Microwave assisted synthesis of quinoxaline derivatives

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Substituted quinoxalines are known building blocks for compounds with pharmacological, agricultural, and material uses.Forming carbon-heteroatom bonds at the 2,3-positions on quinoxaline can be challenging.2,3-chloroquinoxaline Effects Pedal can undergo nucleophilic aromatic substitution however it must be in the presence of metal catalysts.A range of nucleophiles are investigated to showcase the broad range of potential substitution partners that can be incorporated effectively into the 2,3-disubstituted scaffold.

This research focuses on a robust microwave-assisted one-pot procedure to gain efficient access to symmetrically 2,3-substituted Vanity quinoxalines without the use of a metal catalyst.